The American Heart Association urges individuals to call a doctor if signs like discomfort in the center of the chest that feels like uncomfortable pressure, squeezing, fullness or pain persists for more than a few minutes. Heart attack symptoms differ between genders. Women may have chest pain, shortness of breath, nausea, back, or jaw pain. Men and women experience heart attacks differently, with chest pain, anxiety, and radiating discomfort being common signs requiring urgent medical care.